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New Lung Cancer Assay Ready for Prime Time

The assay outperformed clinical criteria in identifying patients with early-stage nonsmall-cell lung cancer who were at high risk and who could benefit from additional treatment.
Medscape Medical News

Source: Medscape Medical News Headlines | 27 Jan 2012 | 8:54 am

New Predictors May Determine Metabolic Risk in Kids on Atypicals

Large waist circumference and a specific genetic variation may be accurate predictors of an increased risk for metabolic syndrome in children prescribed second-generation antipsychotics.
Medscape Medical News

Source: Medscape Medical News Headlines | 27 Jan 2012 | 8:22 am

Long-Term Survival Benefits in Colon Cancer With Oxaliplatin

A capecitabine/oxaliplatin regimen significantly improves survival in stage III colon cancer, compared with 5-fluorouracil/leucovorin, even 7 years after treatment.
Medscape Medical News

Source: Medscape Medical News Headlines | 27 Jan 2012 | 6:16 am

Oral HPV Infection: Higher in Men, Transmitted by Sex

A much higher incidence of human papillomavirus (HPV) in men than women raises the question of whether boys should be getting the HPV vaccine in addition to girls.
Medscape Medical News

Source: Medscape Medical News Headlines | 27 Jan 2012 | 5:43 am

Test May Evaluate Severity of COPD Exacerbation

A new study suggests that a COPD assessment test can determine exacerbation severity.
Medscape Medical News

Source: Medscape Medical News Headlines | 27 Jan 2012 | 5:04 am

Yes to careful introduction of robot assisted surgery

From the perspective of Scotland’s only high volume laparoscopic prostatectomy centre we agree that “even the staunchest laparoscopic urologists would like to use a robot.”1 Although outcomes from...

Source: Latest headlines from BMJ | 8 Nov 2011 | 4:06 am

Prescribing bevacizumab off-label contravenes GMC advice

Jackson and Kirkpatrick recommend adopting cheaper bevacizumab over more expensive ranibizumab to treat wet age related macular degeneration.1 However, their cost projections “do not consider any...

Source: Latest headlines from BMJ | 8 Nov 2011 | 4:06 am

Deadly legacy of GMC's Southall hearings fiasco

Professor David Southall must have been investigated more than any other doctor.1 He has appeared before the General Medical Council on five separate charges, and has been investigated by the police,...

Source: Latest headlines from BMJ | 8 Nov 2011 | 4:06 am

Food allergy information and deriving action levels for use

We agree that consumers with food allergies need clear information about the risks of allergens being accidently present in food,1 but changes to existing practices must be based on robust scientific...

Source: Latest headlines from BMJ | 8 Nov 2011 | 4:06 am

Risk of diabetes from statins may be higher in women

In their editorial Byrne and Wild grapple with the “paradox that arises” when statins, targeted to lower cardiovascular risk, increase diabetes, one of the most potent cardiovascular risk factors.1...

Source: Latest headlines from BMJ | 8 Nov 2011 | 4:06 am

Clinical Evaluation of the Knee

The knee is one of the most complex joints in the body. Knee complaints are the second most common musculoskeletal symptom evaluated by the primary care physician. Anatomy The anatomy...

Source: NEJM Most Viewed Articles | 21 Jul 2010 | 5:00 pm

A Randomized Trial of Treatment for Acute Anterior Cruciate Ligament Tears

Background: The optimal management of a torn anterior cruciate ligament (ACL) of the knee is unknown. We conducted a randomized, controlled trial involving 121 young, active adults with acute...

Source: NEJM Most Viewed Articles | 21 Jul 2010 | 5:00 pm

Congenital Cholesteatoma of the Middle Ear

A 9-year-old boy was referred to an otolaryngologist for subjective right-sided hearing loss. A hearing test revealed mild conductive hearing loss at low and middle frequencies. Otoendoscopy showed a mass with the appearance of a . . .

Source: NEJM - Image of the Week | 21 Jul 2010 | 3:00 pm

The Case for Primary Care — A Medical Student's Perspective

Ms. J. was no stranger to medical students. The year before I came along, she'd worked with another student, and she took unabashed pleasure in sharing the teachable complexities of...

Source: NEJM Most Viewed Articles | 14 Jul 2010 | 5:00 pm

Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis

Background: Cyclophosphamide induction regimens for antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis are effective in 70 to 90% of patients, but they are associated with high rates of death and adverse events....

Source: NEJM Most Viewed Articles | 14 Jul 2010 | 5:00 pm

Paget–Schroetter Syndrome

A 47-year-old woman with no medical history presented with swelling, pain, and reddish discoloration of the right arm and hand after strenuous effort. Findings on ultrasonography, computed tomography, and magnetic...

Source: NEJM Most Viewed Articles | 14 Jul 2010 | 5:00 pm

Paget–Schroetter Syndrome

A 47-year-old woman with no medical history presented with swelling, pain, and reddish discoloration of the right arm and hand after strenuous effort. Findings on ultrasonography, computed tomography, and magnetic resonance imaging were normal. The . . .

Source: NEJM - Image of the Week | 14 Jul 2010 | 3:00 pm

Peripheral Ulcerative Keratitis in Wegener's Granulomatosis

An otherwise healthy 15-year-old girl reported progressively worsening pain and redness in her left eye during the previous 2 months. The diagnosis of scleritis with peripheral ulcerative keratitis in the left eye (Panel A) . . .

Source: NEJM - Image of the Week | 7 Jul 2010 | 3:00 pm

Not All That Wheezes Is Bronchial Asthma

A 10-year-old previously healthy girl presented with episodic wheezing, dyspnea, and progressive exercise intolerance, which had developed during the preceding 9 months. On physical examination, the patient had moderate bilateral expiratory wheezing. She was treated . . .

Source: NEJM - Image of the Week | 30 Jun 2010 | 3:00 pm

Benign Paroxysmal Positional Vertigo

Benign paroxysmal positional vertigo is a common peripheral vestibular disorder. It is caused by loose otoconia, which detach from the utricular macula and fall into any one of the three semicircular canals. Patients report . . .

Source: NEJM - Image of the Week | 23 Jun 2010 | 3:00 pm

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