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A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis
Background: Oral fingolimod, a sphingosine-1-phosphate–receptor modulator that prevents the egress of lymphocytes from lymph nodes, significantly improved relapse rates and end points measured on magnetic resonance imaging (MRI), as compared...Source: NEJM Most Viewed Articles | 3 Feb 2010 | 4:00 pm
Bleeding Esophageal Varices
A 52-year-old man with cirrhosis associated with alcohol abuse presented to the emergency department with hematemesis and lightheadedness, which had developed 3 hours earlier, after binge drinking. He had no...Source: NEJM Most Viewed Articles | 3 Feb 2010 | 4:00 pm
A Wii Fracture
To the Editor: In 1990, Brasington described “Nintendinitis”1 in a patient with pain over the extensor tendon of her thumb after 5 hours of playing a Nintendo video game. Nintendo...Source: NEJM Most Viewed Articles | 3 Feb 2010 | 4:00 pm
Under Pressure
A 25-year-old woman presented to her local hospital with dyspnea. She described a 2-year history of progressive shortness of breath on exertion. One year earlier she was able to walk...Source: NEJM Most Viewed Articles | 3 Feb 2010 | 4:00 pm
Kinked Carotids
An 80-year-old woman presented with congestive heart failure due to aortic insufficiency associated with a markedly dilated ascending aorta. On physical examination, she was noted to have a pulsatile mass...Source: NEJM Most Viewed Articles | 3 Feb 2010 | 4:00 pm
Hydropneumothorax
A 47-year-old man with a history of cirrhosis associated with alcohol abuse presented with a 2-day history of shortness of breath. Before this symptom developed, he had been treated with repeated thoracentesis of the right . . .
Source: NEJM - Image of the Week | 20 Jan 2010 | 2:00 pm
Postoperative Tracheal Stenosis
A 45-year-old woman presented for an assessment of breathlessness. She had been receiving inhaled bronchodilators and corticosteroids for years without improvement. Her medical history was notable for prolonged endotracheal intubation 8 years earlier. Examination revealed . . .
Source: NEJM - Image of the Week | 13 Jan 2010 | 2:00 pm
Necrolytic Migratory Erythema
A 63-year-old woman with a 4 1/2-year history of diabetes mellitus presented with an ulcerating rash, primarily on the shins, groin, and face (Panel A); cheilitis (Panel B); and glossitis. Her symptoms had been worsening . . .
Source: NEJM - Image of the Week | 6 Jan 2010 | 2:00 pm
Radiation Pneumonitis after Radiotherapy for Breast Cancer
A 58-year-old woman with a history of stage I cancer in the right breast (T1N0M0, according to the tumor–node–metastasis classification) presented with a 2-week history of shortness of breath and cough. Eight months before presentation, . . .
Source: NEJM - Image of the Week | 30 Dec 2009 | 2:00 pm
Coughing and Masks
Coughing can transmit infectious agents, such as influenza virus, and it has been assumed that wearing a mask limits transmission of these agents. Schlieren optics can effectively visualize the dispersion of expelled air during . . .
Source: NEJM - Image of the Week | 23 Dec 2009 | 2:00 pm
US Preparing for Fall H1N1 Flu Season
Public health officials and delegations from 54 states, tribes, and territories at the H1N1 Influenza Preparedness Summit discussed a 4-pronged approach to preparation for the fall 2009 influenza season.Medscape Medical News
Source: Medscape Medical News Headlines | 10 Jul 2009 | 10:43 am
Dietary Nutrient Composition Associated With Cirrhosis, Liver Cancer
Dietary composition may affect the progression of cirrhosis and liver cancer, according to results of a large cohort study.Medscape Medical News
Source: Medscape Medical News Headlines | 10 Jul 2009 | 9:35 am
Etanercept May Benefit Children With New-Onset Type 1 Diabetes
Treatment with etanercept in pediatric patients with newly diagnosed type 1 diabetes lowers A1C and increases endogenous insulin production, according to findings published in the July issue of Diabetes Care.Reuters Health Information
Source: Medscape Medical News Headlines | 10 Jul 2009 | 9:24 am
Etanercept Safe and Effective in Refractory RA
Etanercept is a safe and effective adjunct to, or a replacement for, sulfasalazine in rheumatoid arthritis (RA) patients showing an inadequate response to treatment with sulfasalazine alone, researchers report in the July issue of Annals of the Rheumatic Diseases.Reuters Health Information
Source: Medscape Medical News Headlines | 10 Jul 2009 | 9:24 am
Anemia After Complicated Myocardial Infarction Worsens Outcomes
Anemia in patients with a recent acute myocardial infarction complicated by heart failure is associated with an increased risk of hospitalization and mortality, according to a report in the June issue of the European Heart Journal.Reuters Health Information
Source: Medscape Medical News Headlines | 10 Jul 2009 | 9:24 am